Endocrine Abstracts

Introduction: The incidence of cancer has increased in case of diabetes, as well as the metabolic abnormalities observed during diabetes could have a critical role on carcinogen, nevertheless one should not deny the implication of common factors to diabetes and cancer (obesity, smoking, advanced age, etc).Study objectives: Describe the biological and morphological screening methods for neoplasia in the event of weight loss concomitant with chronic glycem...

Peripartum hyponatraemia is an under-recognised complication of labour and poses a risk to both mother and baby. It is typically caused by water intoxication for physiological reasons and population health trends around water intake. We have recent experience of managing 2 patients with severe symptomatic hyponatraemia. Both patients had increased their oral intake of fluid during labour as well as receiving intravenous fluids. Dilutional hyponatraemia was found to be the unde...

Background: Tako-tsubo cardiomyopathy (TTC) is a non-ischemic condition manifested with a temporary weakening of the myocardium after an acute stress. The association between pheochromocytoma (PHEO) and TTC is rare and is attributed to catecholamine excess. We present a case of a young women with an atypical manifestation of PHEO.Clinical case: Patient, F, aged 37, known with multinodular goiter with hypothyroidism for several years, having paroxysmal hy...

Introduction: Continuous subcutaneous insulin infusion (CSII) represents a treatment option that helps patients with type 1 diabetes (PwT1D) to achieve better glycemic control, reduces hypoglycemia and improves quality of life. In Portugal, the National Health System (SNS) affords CSII treatment to PwT1D, according to certain criteria. Over the years, the number of patients treated with CSII devices supported by SNS has grown exponentially. We analyzed these patient’s pro...

Introduction: Sheehan syndrome (SS) is caused by postpartum necrosis of the pituitary gland, associated with significant haemorrhage during or after delivery. It is rare in developed countries, but still frequent in underdeveloped ones. We present a rare presentation of this syndrome.Clinical case: A 48 years old black woman presented at the emergency department for long term fatigue and dyspnea that worsened a few days before. Her physical examination r...

Introduction and aim: In the UK, 15% of couples are affected by infertility which is due to primary or secondary male factors in 30%. Induction of spermatogenesis with gonadotrophins is a long established endocrine treatment for gonadotrophin deficiency. However, there are concerns that some patient groups have very low success rates. The aim of our audit was to define success of spermatogenesis and fertility rates amongst these men.Methods: We retrospec...

Background: Maturity onset diabetes of the young (MODY) has an estimated prevalence of 1–5% in the diabetic population, but misdiagnosis as type 1 or type 2 diabetes is common. It comprises a heterogeneous group of monogenic diseases characterized by primary dysfunction of β cell, young onset, autosomal dominant inheritance, without autoimmunity and without ketosis. Early diagnosis remains a challenge with important future implications, since it allows treatment opti...

Introduction: In congenital hyperinsulinism (CHI) hypoglycaemia results from a dysregulation of insulin secretion. We hypothesised that other pancreatic hormones may also be dysregulated in this condition.Objectives: To proof the applicability of Luminex Multiplex method to measure pancreatic hormones (insulin, C-peptide, glucagon, amylin and PP) in the paediatric age. To elucidate the fasting response of these hormones in children with different forms o...

Background: Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia and is due to the unregulated secretion of insulin from the pancreatic beta-cells. The role of gut hormones and dipeptidyl peptidase-4 (DPP-4) is currently unknown in patients with CHI.Aims: To evaluate the expression pattern of DPP-4 in focal and diffuse CHI.Method: Using intra-operative formalin-fixed paraffin embedded (FFPE) pancreati...

We previously have reported that short-term treatment of mice with recombinant hGH leads to significant increases in bodyweight (BW), lean body mass (LBM) and liver weight, but – unlike in humans – does not robustly increase circulating levels of IGF1. We now tested the hypothesis that formation of neutralizing antibodies in mice treated with rhGH could explain the lack of IGF1 response. Therefore, we intentionally induced antibody formation against hGH in female FVB...